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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Hydroxypropyl-β-cyclodextrin-containing hydrogel enhances skin formononetin permeation/retention
Paula Hollweg Dias1, Marina Scopel1, Simony Martiny1
1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
The Journal of Pharmacy and Pharmacology
|April 11, 2018
Summary
Hydrogels with isoflavones formononetin and biochanin A, especially with hydroxypropyl-β-cyclodextrin, enhance skin permeation. These compounds show potential for anti-aging cosmetic formulations due to skin retention.
Area of Science:
- Pharmacology and Cosmetology
- Dermal Drug Delivery Systems
Background:
- Isoflavones like formononetin and biochanin A possess potential cosmetic benefits.
- Hydrogel formulations and cyclodextrins are explored for enhancing topical delivery.
Purpose of the Study:
- To evaluate the in vitro skin permeation of formononetin and biochanin A in hydrogel formulations.
- To investigate the role of cyclodextrins in enhancing isoflavone skin penetration.
Main Methods:
- In vitro permeation assay using porcine skin on Franz diffusion cells.
- Quantification of isoflavones in skin layers via validated HPLC-PDA method.
Main Results:
- Formononetin permeation was significantly enhanced by hydroxypropyl-β-cyclodextrin in epidermis and dermis.
- Biochanin A showed increased permeation with cyclodextrin incorporation.
- No synergistic permeation effect observed when formononetin and biochanin A were combined.
Conclusions:
- Hydroxypropyl-β-cyclodextrin notably promotes formononetin skin permeation.
- Formononetin and biochanin A effectively permeate and are retained in skin layers.
- These isoflavones demonstrate potential for use in anti-aging cosmetic products.
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