Propagation of Enzyme-Induced Surface Events inside Polymer Nanoassemblies for a Fast and Tunable Response
Jiaming Zhuang1, Hatice Seçinti1, Bo Zhao1
1Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
Abstract:
We report a new molecular design strategy that allows for the propagation of surface enzymatic events inside a supramolecular assembly for accelerated molecular release. The approach addresses a key shortcoming encountered with many of the currently available enzyme-induced disassembly strategies, which rely on the unimer-aggregate equilibria of amphiphilic assemblies. The enzymatic response of the host to predictably tune the kinetics of guest-molecule release can be programmed by controlling substrate accessibility through electrostatic complexation with a complementary polymer. Accelerated guest release in response to the enzyme is shown to be accomplished by a cooperative mechanism of enzyme-triggered supramolecular host disassembly and host reorganization.
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