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Updated: Feb 12, 2026

Identification of Fatty Acids in Bacillus cereus
Published on: December 5, 2016
Identification of novel antilipogenic agents targeting fatty acid biosynthesis through structure-based virtual
Laurent Soulère1, Pascaline M Alix2, Marine L Croze2
1Univ Lyon, INSA Lyon, UMR 5246, CNRS, Université Lyon 1, CPE Lyon, ICBMS, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Villeurbanne, France.
Abstract:
An Asinex Gold Platinium chemical library subset of 12 055 compounds was screened employing docking simulations in the active site of the human FAS KS domain. Among them, 13 compounds were further evaluated for their ability to inhibit fatty acid biosynthesis. Four compounds were found to be active in particular ASN05064661 and ASN05374526 with IC50 values of 6.6 and 10.5 μm, respectively. A binding mode study was further conducted with these two compounds structurally related to benzene sulfonamide and aromatic polyamide. This study showed that they fit tightly with the active site with several interactions, notably with the key residues Cys161, His293, and His331.
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