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Sulfur, an important element in the chemical makeup of proteins, is recycled through the atmosphere and aquatic and terrestrial environments. Found in the atmosphere as sulfur dioxide (SO2), sulfur is released by decaying organisms, weathered rocks, geothermal vents, volcanos, and burning fossil fuels. It is deposited into the ecosystem, cycled through the biotic community, and either released back into the atmosphere as gas or deposited in marine sediment for long-term storage and eventual...
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Sulfur-Sulfur Bond Construction.

Ming Wang1, Xuefeng Jiang2

  • 1School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, People's Republic of China.

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|April 12, 2018
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Summary
This summary is machine-generated.

This chapter reviews recent methods for synthesizing disulfide compounds, focusing on creating unsymmetrical disulfides. These techniques are crucial for developing new pharmaceuticals and understanding chemical biology.

Keywords:
ADCDisulfideNatural productsPharmaceuticals

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Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Chemical Biology

Background:

  • Disulfide bonds are vital structural elements found in numerous pharmaceuticals, natural products, and biological molecules.
  • Understanding the synthesis of disulfide-containing compounds is essential for drug discovery and chemical biology research.

Purpose of the Study:

  • To provide a comprehensive overview of recent synthetic methodologies for disulfide-containing compounds.
  • To highlight specific strategies for the efficient synthesis of unsymmetrical disulfides.

Main Methods:

  • The review categorizes synthetic approaches based on the structural features of the target disulfides.
  • It details various chemical reactions and strategies employed for disulfide bond formation.
  • Emphasis is placed on methods suitable for constructing unsymmetrical disulfide linkages.

Main Results:

  • Recent advancements have expanded the toolkit for synthesizing diverse disulfide structures.
  • Specific methods enable controlled formation of unsymmetrical disulfides, overcoming previous limitations.
  • The reviewed methodologies offer practical solutions for accessing complex disulfide-containing molecules.

Conclusions:

  • The development of novel synthetic routes facilitates the creation of valuable disulfide-containing compounds.
  • These advancements support the design and synthesis of new therapeutic agents and chemical probes.
  • The organized presentation aids researchers in selecting appropriate methods for their specific synthetic targets.