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Related Concept Videos

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Related Experiment Video

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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Healthcare resources utilisation in primary progressive multiple sclerosis.

Carlo Piccinni1, Giulia Ronconi2, Silvia Calabria2

  • 1CORE srl-Collaborative Outcome Research, Via Magnanelli 2, 40033 Casalecchio di Reno, Bologna, Italy. piccinni@coreteam.it.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|April 12, 2018
PubMed
Summary

Primary progressive multiple sclerosis (PPMS) impacts 10% of multiple sclerosis patients in Italy, incurring significant healthcare costs. This study quantifies the annual cost per PPMS patient for the Italian National Health System (INHS).

Keywords:
Administrative databasesBurden of diseaseItalyPrimary progressive multiple sclerosisReal-world evidence

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Area of Science:

  • Epidemiology and Health Economics
  • Neurology and Public Health

Background:

  • Epidemiological data on primary progressive multiple sclerosis (PPMS) are limited.
  • Understanding the healthcare burden and costs associated with PPMS is crucial for resource allocation.

Purpose of the Study:

  • To evaluate the healthcare resource utilization and costs of PPMS for the Italian National Health System (INHS).
  • To provide a reliable estimation of the PPMS burden in Italy.

Main Methods:

  • A 2-year cross-sectional analysis of real-world data from the ARCO database (>10 million inhabitants).
  • Identification of PPMS patients based on absence of disease-modifying treatments and use of rehabilitation services.
  • Analysis of drug prescriptions, outpatient services, and hospitalizations in 2015.

Main Results:

  • The prevalence of PPMS in Italy was estimated at 10% of the multiple sclerosis (MS) population (1849 patients).
  • PPMS patients exhibited high healthcare utilization: 26.8% hospitalizations, 97.3% outpatient services, and 94.3% reimbursed drug use.
  • The average annual cost per PPMS patient for the INHS was €3783, with 49% attributed to hospitalizations, 28% to outpatient services, and 23% to drugs.

Conclusions:

  • This study provides a reliable estimation of the PPMS healthcare burden and direct costs in Italy.
  • Findings can inform health expenditure projections, especially considering the introduction of new PPMS therapies.
  • Future cost analyses should account for potential shifts from rehabilitation/hospitalization costs to pharmaceutical expenditures.