Related Experiment Video
Updated: Feb 12, 2026
09:53
Gene Editing of Primary Rhesus Macaque B Cells
Published on: February 10, 2023
3.0K
Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo
Ting Xu1, Arnaud Falchier2, Elinor L Sullivan3
1Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Cell Reports
|April 12, 2018
Summary
Functional brain mapping in non-human primates (NHPs) using fMRI can create individual-specific brain fingerprints. Data requirements for reproducible parcellations were established, showing state-dependent connectivity differences.
Area of Science:
- Neuroscience
- Neuroimaging
Background:
- Histology-based brain mapping is traditional, but functional magnetic resonance imaging (fMRI) is advancing macroscale brain organization delineation.
- Non-human primates (NHPs) are crucial models for overcoming translational research barriers in neuroscience.
Purpose of the Study:
- To establish data requirements for reproducible and valid individual-specific brain parcellations in NHPs.
- To investigate the impact of different scanning states (awake vs. anesthetized) on functional connectivity and parcellation.
Main Methods:
- Utilized fMRI to map functional brain organization in individual NHPs.
- Collected data under both awake (rest, naturalistic viewing) and anesthetized conditions.
- Compared functional connectivity patterns across different states and brain regions.
Main Results:
- Demonstrated that functional boundaries act as individual-specific fingerprints in NHPs.
- Achieved reproducible parcellations under both awake and anesthetized conditions.
- Observed state-dependent differences in connectivity, particularly in higher-order association, visual, and motor cortices, precluding cross-state individual identification.
Conclusions:
- Established the feasibility and data requirements for generating reproducible, individual-specific brain parcellations in NHPs.
- Highlighted the significant impact of scanning state on functional connectivity, necessitating protocol harmonization.
- Provided insights into state-dependent neural processing in various cortical areas.
More Related Videos
Related Concept Videos
01:21Association Areas of the Cortex
9.5K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.5K
01:09Levels of Organization
141.7K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
141.7K
01:31Accessory Organs
74.5K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
74.5K
03:02Organic Compounds
57.6K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
57.6K
00:53Transgenic Organisms
33.6K
Overview
33.6K
01:14Motor and Sensory Areas of the Cortex
7.7K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
7.7K