Coronary Artery Development: Origin, Malformations, and Translational Vascular Reparative Therapy
Daryl Ramai1,2, Jonathan Lai2, Constantine Monzidelis1
11 Department of Medicine, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, Brooklyn, NY, USA.
Journal of Cardiovascular Pharmacology and Therapeutics
|April 13, 2018
Summary
Coronary artery development involves a primitive vascular network and three main sources: proepicardium, sinus venosus, and endocardium. Understanding these pathways is crucial for heart disease and vascular regeneration research.
Area of Science:
- Cardiovascular Biology
- Developmental Biology
- Angiogenesis Research
Background:
- Cardiac chamber thickening during embryogenesis necessitates a vascular network for cell survival.
- The primitive vascular plexus matures into coronary arteries and veins, essential for heart development.
- Previous models of coronary artery growth are being refined by recent lineage-tracing studies.
Purpose of the Study:
- To review current trends in coronary artery development.
- To explore cellular and molecular signals regulating heart vascularization.
- To discuss implications for heart disease and vascular regeneration.
Main Methods:
- Review of lineage-tracing studies identifying progenitor cell sources.
- Analysis of cellular and molecular mechanisms in heart vascularization.
- Synthesis of current research on coronary artery development.
Main Results:
- Lineage-tracing studies identified three major sources for coronary arteries: proepicardium, sinus venosus, and endocardium.
- The precise contribution of each source to coronary vascularization is still under investigation.
- An emerging model highlights alternative pathways and progenitor cells crucial for successful coronary angiogenesis.
Conclusions:
- Coronary artery development is a complex process involving multiple progenitor sources.
- Understanding these developmental pathways is vital for addressing cardiovascular diseases.
- Further research into heart vascularization holds promise for therapeutic strategies in vascular regeneration.
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