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Updated: Feb 12, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?
Gilbert H Smith1, Daniel Medina2
1Mammary Stem Cell Biology, BRL,CCR, NCI, NIH, Bethesda, MD, 20892, USA. gs4d@nih.gov.
Abstract:
The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition.
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