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The Linear Noise Approximation for Spatially Dependent Biochemical Networks
1Division of Scientific Computing, Department of Information Technology, Uppsala University, SE-75105, Uppsala, Sweden. perl@it.uu.se.
Abstract:
An algorithm for computing the linear noise approximation (LNA) of the reaction-diffusion master equation (RDME) is developed and tested. The RDME is often used as a model for biochemical reaction networks. The LNA is derived for a general discretization of the spatial domain of the problem. If M is the number of chemical species in the network and N is the number of nodes in the discretization in space, then the computational work to determine approximations of the mean and the covariances of the probability distributions is proportional to [Formula: see text] in a straightforward implementation. In our LNA algorithm, the work is proportional to [Formula: see text]. Since N usually is larger than M, this is a significant reduction. The accuracy of the approximation in the algorithm is estimated analytically and evaluated in numerical experiments.
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