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Updated: Feb 12, 2026
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
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PREPARATION AND EVALUATION OF pH RESPONSIVE POLY(2-HYDROXYETHYL METHACRYLATE-CO-ITACONIC ACID) MICROGELS FOR
Acta Poloniae Pharmaceutica
|April 13, 2018
Summary
pH-sensitive microgels were developed for controlled drug delivery. These p(HEMA-co-IA) microgels show potential as carriers for site-specific esomeprazole magnesium trihydrate (EMT) release.
Area of Science:
- Polymer Chemistry
- Materials Science
- Pharmaceutics
Background:
- Developing effective drug delivery systems is crucial for targeted and controlled therapeutic outcomes.
- Microgels offer tunable properties for encapsulating and releasing active pharmaceutical ingredients.
- pH-responsive materials are desirable for site-specific drug delivery, particularly in the gastrointestinal tract.
Purpose of the Study:
- To synthesize and characterize pH-sensitive microgels for potential use in drug delivery.
- To investigate the loading and in vitro release kinetics of esomeprazole magnesium trihydrate (EMT) from these microgels.
Main Methods:
- Modified free radical suspension polymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) with ethylene glycol dimethacrylate (EGDMA) crosslinker.
- Equilibrium swelling technique for drug loading.
- Characterization using FTIR, TGA, DLS, SEM, and in vitro drug release studies.
Main Results:
- Copolymer network formation of p(HEMA-co-IA) confirmed by FTIR and TGA.
- SEM and DLS showed uniform, spherical microgels with particle sizes up to 10 μm.
- Microgels exhibited pH-responsive swelling and drug release following the Higuchi model with non-Fickian diffusion.
Conclusions:
- p(HEMA-co-IA) microgels are successfully synthesized and exhibit pH-sensitive behavior.
- These microgels demonstrate potential as effective carriers for site-specific and controlled drug delivery of EMT.
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