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Updated: Feb 12, 2026

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Three-Component Site-Selective Synthesis of Highly Substituted 5 H-Chromeno-[4,3- b]pyridines
Cong-Hai Zhang1, Rong Huang1, Xing-Mei Hu1
1Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , 650091 , P. R. China.
Abstract:
An efficient and concise one-pot procedure was developed based on a cascade reaction of 3-formylchromones 1 and different types of 1,1-enediamines (EDAMs) 2 with different alcohols or amines 3 by a site-selective synthesis of 5 H-chromeno[4,3- b]pyridines in an environmentally friendly solvent. This protocol is especially suitable for the efficient and rapid parallel synthesis of 5 H-chromeno[4,3- b]pyridine compounds. It also has some advantages, such as convenience of operation, short reaction times, use of a green solvent, and ease of purification by washing the crude products with ethanol.
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