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Is Exercise the Right Medicine for Dystrophic Muscle?
Hannah R Spaulding1, Joshua T Selsby
1Department of Animal Science, Iowa State University, Ames, IA.
Medicine and Science in Sports and Exercise
|April 13, 2018
Summary
Exercise shows potential for Duchenne muscular dystrophy (DMD) by improving limb muscles in mice and respiratory function in humans. However, long-term effects on cardiac and respiratory muscles require further investigation for safe exercise prescription in DMD patients.
Area of Science:
- Neuromuscular diseases
- Exercise physiology
Background:
- Duchenne muscular dystrophy (DMD) results from dystrophin deficiency, leading to progressive muscle damage.
- Dystrophin is crucial for muscle fiber stability during contraction.
- DMD patients face muscle necrosis, functional loss, and potential respiratory or cardiac failure.
Purpose of the Study:
- To review exercise literature concerning dystrophin-deficient muscle.
- To identify trends and knowledge gaps in exercise interventions for DMD.
Main Methods:
- Compilation and analysis of existing mouse and human studies on exercise and DMD.
- Focus on various exercise modalities and their effects.
Main Results:
- Endurance exercises (swimming, wheel running) show therapeutic potential for limb muscles in mice.
- Respiratory training demonstrated benefits in human DMD patients.
- Contradictory findings exist regarding long-term, low-intensity training effects on cardiac and respiratory muscles.
- The impact of exercise on other bodily systems in DMD remains largely unexplored.
Conclusions:
- Multisystemic investigations are essential for safe exercise prescription in DMD.
- Further research must evaluate the effects of exercise on cardiac and respiratory muscles in DMD patients.
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