Related Experiment Video
Updated: Feb 12, 2026

Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids
Published on: December 13, 2017
Centrosome Positioning in Dictyostelium: Moving beyond Microtubule Tip Dynamics
Michael P Koonce1, Irina Tikhonenko2
1Division of Translational Medicine, New York State Department of Health, Wadsworth Center, Albany, NY 12201-0509, USA. michael.koonce@health.ny.gov.
Abstract:
The variability in centrosome size, shape, and activity among different organisms provides an opportunity to understand both conserved and specialized actions of this intriguing organelle. Centrosomes in the model organism Dictyostelium sp. share some features with fungal systems and some with vertebrate cell lines and thus provide a particularly useful context to study their dynamics. We discuss two aspects, centrosome positioning in cells and their interactions with nuclei during division as a means to highlight evolutionary modifications to machinery that provide the most basic of cellular services.
Related Concept Videos
Microtubules
Microtubules
Microtubules have two structurally similar globular protein subunits: α and β tubulins. In the cytosol, the α and β tubulins form a heterodimer....
Centrioles and Centrosomes
Near the end of the prophase, also called late prophase or...
Centrosome Duplication
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Position-effect Variegation
Microtubule Instability

