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Updated: Feb 12, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Probing the brain with molecular fMRI.

Souparno Ghosh¹, Peter Harvey¹, Jacob C Simon¹

¹Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Rm. 16-561, Cambridge, MA 02139, United States.

Current Opinion in Neurobiology

|April 13, 2018

Summary

This summary is machine-generated.

Molecular functional MRI (fMRI) bridges brain scales by mapping microscopic neural activity in vivo. This review explores novel probes and methods for advanced brain imaging, potentially aiding human neuroscience research.

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Last Updated: Feb 12, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

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Simultaneous fMRI and Electrophysiology in the Rodent Brain

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Published on: August 19, 2010

Area of Science:

Neuroscience
Molecular Imaging
Brain Function

Background:

Integrating molecular-level neuroscience with organismic-scale brain function models is a major challenge.
Current imaging techniques struggle to bridge these physiological scales in the living brain.

Purpose of the Study:

To review the potential of molecular functional magnetic resonance imaging (fMRI) to link molecular and cellular brain processes to behavior and cognition.
To explain how MRI-detectable probes can enhance noninvasive imaging of neural processing.

Main Methods:

Utilizing MRI-detectable imaging probes to sensitize noninvasive imaging.
Combining innovative probe design, advanced imaging techniques, and brain delivery strategies.
Focusing on spatiotemporally resolved studies of neural phenomena.

Main Results:

Molecular fMRI offers a novel approach to map microscopic phenomena in optically inaccessible brain regions.
The integration of probe design, imaging methods, and delivery strategies is key to successful molecular fMRI.
This technology has the potential for diverse neural studies.

Conclusions:

Molecular fMRI is a promising technology for bridging scales in neuroscience.
Further advancements in probes, methods, and delivery will enhance its application.
Potential future applications may include human studies of brain function.