Related Experiment Video
Updated: Feb 12, 2026
Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
Published on: October 24, 2012
Advanced dynamic statistical parametric mapping with MEG in localizing epileptogenicity of the bottom of sulcus
Midori Nakajima1, Simeon Wong2, Elysa Widjaja3
1Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan.
Objective:
To investigate whether advanced dynamic statistical parametric mapping (AdSPM) using magnetoencephalography (MEG) can better localize focal cortical dysplasia at bottom of sulcus (FCDB).
Methods:
We analyzed 15 children with diagnosis of FCDB in surgical specimen and 3 T MRI by using MEG. Using AdSPM, we analyzed a ±50 ms epoch relative to each single moving dipole (SMD) and applied summation technique to estimate the source activity. The most active area in AdSPM was defined as the location of AdSPM spike source. We compared spatial congruence between MRI-visible FCDB and (1) dipole cluster in SMD method; and (2) AdSPM spike source.
Results:
AdSPM localized FCDB in 12 (80%) of 15 children whereas dipole cluster localized six (40%). AdSPM spike source was concordant within seizure onset zone in nine (82%) of 11 children with intracranial video EEG. Eleven children with resective surgery achieved seizure freedom with follow-up period of 1.9 ± 1.5 years. Ten (91%) of them had an AdSPM spike source in the resection area.
Conclusion:
AdSPM can noninvasively and neurophysiologically localize epileptogenic FCDB, whether it overlaps with the dipole cluster or not.
Significance:
This is the first study to localize epileptogenic FCDB using MEG.
Related Concept Videos
01:12Statistical Methods to Analyze Parametric Data: ANOVA
One-way ANOVA is applied when a single independent variable or factor is scrutinized. It compares...
01:09Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test
The Student's t-test is a statistical test that examines if there is a statistically significant difference between the means of two groups. This test is instrumental when dealing with...
01:16Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
01:50Statistical Significance
01:14Probability in Statistics
An example of a simple event is a coin toss. The result of a coin toss is either a head or a tail. Here, head and tail are two simple events. These two simple events make up the sample space. Further, the probability of an event occurring falls within the range of 0 to 1. The probability of an...
01:17Introduction to Statistics
In statistics, the collection of individuals or objects under study is called population. The idea of sampling is to select a portion of the larger population...