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The autonomic nervous system and fatigue.
1Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
Functional Neurology
|October 1, 1987
Summary
This study explores fatigue, examining how conditions like multiple sclerosis, heat stroke, and altitude affect the body. It highlights changes in neuropeptides, opioids, and autonomic function during exertion and disease.
Area of Science:
- Physiology
- Neuroscience
- Exercise Science
Background:
- Fatigue, though similarly symptomatic, has distinct behavioral, physiological, and exertional definitions.
- Amantadine shows benefits for fatigue in multiple sclerosis, linked to circulatory neuropeptide and lactate shifts.
- Exercise can disrupt thermoregulation, potentially leading to heat stroke, which involves increased endogenous opioids.
Purpose of the Study:
- To investigate the complex physiological and neurological factors underlying various types of fatigue.
- To explore the role of specific neurochemicals and autonomic responses in conditions like multiple sclerosis, heat stroke, and altitude sickness.
- To understand the impact of endurance training and environmental factors on physiological regulation and fatigue.
Main Methods:
- Review of existing literature on fatigue, amantadine effects, heat stroke pathophysiology, and exercise physiology.
- Analysis of changes in neuropeptides, lactate, opioids, and autonomic nervous system activity.
- Examination of hormonal secretion, feedback mechanisms, and cranial blood flow during exertion and at altitude.
Main Results:
- Amantadine's efficacy in multiple sclerosis fatigue correlates with circulatory neuropeptide and lactate alterations.
- Heat stroke is associated with elevated endogenous opioids, suggesting potential therapeutic targets.
- Endurance training significantly alters sympathetic and parasympathetic function, hormonal responses, and feedback mechanisms during prolonged exertion.
- Altitude exposure increases cranial blood flow, potentially contributing to acute mountain sickness.
- Autonomic function exhibits circadian variations, impacting conditions like cluster headaches and response to vagal stimulation for hiccups.
Conclusions:
- Fatigue is a multifaceted condition influenced by diverse physiological, neurological, and environmental factors.
- Understanding these complex interactions offers insights into therapeutic strategies for fatigue-related disorders and conditions exacerbated by exertion or environmental stress.
- Further research into neurochemical and autonomic regulation is crucial for managing fatigue and related pathologies.