Pathophysiology of Long Non-coding RNAs in Ischemic Stroke.

Area of Science:

• Neurology
• Molecular Biology
• Genetics

Background:

• Ischemic stroke is a leading cause of death and disability, characterized by complex pathophysiologic processes.
• Key mechanisms include oxidative stress, excitotoxicity, calcium overload, apoptosis, and inflammation.
• Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular processes.

Purpose of the Study:

• To review the involvement of lncRNAs in the pathophysiology of ischemic stroke.
• To highlight specific lncRNAs implicated in stroke pathogenesis.
• To explore the potential of lncRNAs as diagnostic biomarkers and therapeutic targets for ischemic stroke.

Main Methods:

• Review of existing literature on lncRNA expression and function in ischemic stroke.
• Analysis of studies involving human blood samples, animal models, and cell models of ischemic stroke.
• Focus on lncRNAs identified in acute ischemic stroke patients and experimental models.

Main Results:

• Altered expression of various lncRNAs has been observed in blood samples of acute ischemic stroke patients.
• lncRNAs play roles in regulating key pathophysiologic events of ischemic stroke.
• Specific lncRNAs are associated with different aspects of stroke pathophysiology.

Conclusions:

• lncRNAs are implicated in the molecular mechanisms underlying ischemic stroke.
• lncRNAs hold significant potential as biomarkers for ischemic stroke diagnosis, prognosis, and treatment.
• Targeting specific lncRNAs may offer novel therapeutic strategies for managing ischemic stroke.