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Central-To-Peripheral Arterial Stiffness Gradient in Hemodialyzed Patients Depends on the Location of the Upper-limb

Daniel Bia1, Cintia Galli2, Yanina Zocalo1

  • 1Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, Montevideo, Uruguay.

Current Hypertension Reviews
|April 14, 2018
PubMed

Insights

Pulse wave velocity ratio (PWV-ratio) is higher on the vascular access (VA) side in hemodialyzed patients, indicating altered arterial stiffness. Researchers should consider the body side when measuring PWV-ratio to ensure accurate findings.

Area of Science:

  • Cardiovascular Physiology
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Pulse wave velocity ratio (PWV-ratio) is a measure of central-to-peripheral arterial stiffness.
  • PWV-ratio is calculated as carotid-femoral PWV (cf-PWV) divided by carotid-radial PWV (cr-PWV).
  • Arterial stiffness may differ based on the side of the body with vascular access (VA).

Purpose of the Study:

  • To compare arterial stiffness parameters between the left and right sides of the body in hemodialyzed and non-hemodialyzed patients.
  • To analyze PWV-ratio values on the VA side versus the contralateral side.
  • To investigate the impact of VA on arterial stiffness measurements.

Main Methods:

  • Used Pearson's correlation and Bland & Altman analysis.
  • Included 135 hemodialyzed and 77 non-hemodialyzed patients.
  • Measured cf-PWV and carotid-brachial PWV (cb-PWV) to calculate PWV-ratio, as cr-PWV measurement is difficult with VA.

Main Results:

  • PWV-ratio was significantly higher on the VA side compared to the contralateral side in hemodialyzed patients.
  • cf-PWV, cb-PWV, and PWV-ratio showed high correlation between the left and right sides of the body.
  • Arterial stiffness measurements were consistently comparable between body sides, except for the VA side in hemodialyzed patients.

Conclusions:

  • PWV-ratio is significantly influenced by the presence of a VA.
  • Arterial stiffness measurements should account for the specific body territory analyzed.
  • Future research on PWV-ratio must consider the location of the VA.
Abstract

Keywords:
Arterial stiffnessPWV-ratioaortic stiffnesshemodialysispulse wave velocityterritory.

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