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Related Experiment Video

Updated: Feb 11, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Published on: March 22, 2020

Stable and oxidant responsive zwitterionic nanoclusters.

Shuaidong Huo¹, Ying Jiang, Ziwen Jiang

¹Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.

|April 14, 2018

Summary

This summary is machine-generated.

Sulfonamide zwitterionic ligands create non-toxic gold nanoclusters (AuNCs) with stable red fluorescence. These AuNCs can detect antioxidants like ascorbic acid in real time by sensing reactive oxygen species.

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Area of Science:

Nanomaterials Science
Biomaterials Engineering
Chemical Sensing

Background:

Zwitterions are valuable for creating non-toxic, non-interacting biomaterials.
Gold nanoclusters (AuNCs) functionalized with specific ligands offer unique optical properties.

Purpose of the Study:

To develop novel zwitterionic ligands for AuNCs.
To investigate the use of these functionalized AuNCs for sensitive and selective biosensing applications.

Main Methods:

Synthesis of sulfonamide-based monothiol zwitterionic ligands.
Fabrication of zwitterion-functionalized AuNCs.
Characterization of colloidal stability and optical properties.
Real-time fluorescence modulation by reactive oxygen species (ROS).

Main Results:

The fabricated AuNCs exhibited stable colloidal properties.
Intense red fluorescence was observed in biological environments.
Fluorescence intensity was modulated by ROS, specifically hydroxyl radicals (˙OH).
Quantitative and selective sensing of antioxidants, such as ascorbic acid, was achieved.

Conclusions:

Sulfonamide-based zwitterionic ligands impart desirable properties to AuNCs for biomaterial applications.
The ROS-modulated fluorescence enables real-time quantitative sensing of antioxidants.
These functionalized AuNCs show potential as advanced biosensors.