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Photothermal-Augmented CoP-Carbon Polyhedral Nanozyme: Redox Homeostasis and Immune Reprogramming Mediated Psoriasis

Beibei Liu1,2, Yongji Xia3, Yuqing Su1,2

  • 1Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

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Cobalt phosphide nanoparticles on carbon frameworks offer a novel therapy for psoriasis. This nanozyme platform combines catalytic and photothermal effects to reduce inflammation and oxidative stress, showing promise for skin disorder treatment.

Keywords:
cobalt phosphide‐carbonimmune reprogrammingnanozymesphotothermal‐enhanced catalysispsoriasis

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Psoriasis is a chronic inflammatory skin disease driven by oxidative stress and immune dysregulation.
  • Current treatments for psoriasis face limitations, necessitating innovative therapeutic approaches.
  • Oxidative stress and immune imbalance are key factors in psoriasis pathogenesis.

Purpose of the Study:

  • To develop and evaluate cobalt phosphide nanoparticles on carbon polyhedral frameworks (CoP-C PFs) as a multifunctional nanoplatform for psoriasis management.
  • To investigate the synergistic effects of enzyme-mimicking catalysis and photothermal activity of CoP-C PFs in treating psoriasis.
  • To assess the therapeutic efficacy and biosafety of CoP-C PFs in a preclinical psoriasis model.

Main Methods:

  • CoP-C PFs were synthesized and characterized for their catalytic and photothermal properties.
  • The reactive oxygen species (ROS) scavenging ability of CoP-C PFs was evaluated in macrophage and keratinocyte cell lines.
  • The therapeutic effect of CoP-C PFs was assessed in an imiquimod-induced psoriatic murine model, analyzing inflammatory markers, immune cell infiltration, and histological changes.

Main Results:

  • CoP-C PFs demonstrated efficient ROS scavenging with low Michaelis-Menten constants (e.g., Km = 0.26 mM for H2O2 decomposition).
  • The nanoparticles exhibited high photothermal conversion efficiency (68.6%) under near-infrared irradiation, enabling localized hyperthermia.
  • In vivo studies showed CoP-C PFs significantly alleviated inflammation, restored redox balance, modulated immune pathways (IL-17A/IL-23, TNF-α/NF-κB), promoted M2 macrophage polarization, and normalized skin structure without organ toxicity.

Conclusions:

  • CoP-C PFs serve as an effective "all-in-one" nanozyme platform for psoriasis treatment by dual regulation of oxidative stress and the immune microenvironment.
  • The integration of photothermal enhancement and multienzyme catalysis offers a promising therapeutic strategy for psoriasis and other inflammatory skin disorders.
  • The study highlights the potential of CoP-C PFs for safe and effective management of inflammatory skin conditions.