Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecularly Engineered Wing-Shaped Azobenzene Memristors for Logic-in-Memory and Edge Visual Intelligence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same author

Comprehensive Metabolomic Profiling of Skin Lesions from Psoriasis Patients Reveals Disease Signatures.

International journal of biological sciences·2026
Same author

Correction to: Puerarin alleviates myocardial ischemia-reperfusion injury by enhancing FUNDC1-mediated mitophagy.

Molecular and cellular biochemistry·2026
Same author

Development of Predictive Models for NB-UVB Treatment Efficacy and Safety in Psoriasis.

Psoriasis (Auckland, N.Z.)·2026
Same author

Control of representation updating by higher-order thalamus enables history-based decision-making.

Neuron·2026
Same journal

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice.

Nature communications·2026
Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026
Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026
Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026
Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026
Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Double-stranded RNA and ROS scavenging nanoplatform for modulating skin inflammation.

Lian Cui1,2, Hengli Lu3, Jiangluyi Cai1,2

  • 1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Nature Communications
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

A novel cerium-doped polyoxometalate, Mo90Ce10, effectively neutralizes double-stranded RNA (dsRNA) and reactive oxygen species (ROS) to combat skin inflammation. This compound offers a promising new therapeutic strategy for inflammatory skin conditions.

More Related Videos

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Related Experiment Videos

Last Updated: May 14, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Area of Science:

  • Materials Science
  • Immunology
  • Dermatology

Background:

  • Double-stranded RNA (dsRNA) and reactive oxygen species (ROS) are key drivers of inflammatory skin diseases like psoriasis and atopic dermatitis.
  • Current treatments primarily focus on antioxidants, with limited options for targeting pathogenic dsRNA.

Purpose of the Study:

  • To investigate the potential of Mo90Ce10, a cerium-doped polyoxometalate, in mitigating dsRNA- and ROS-driven cutaneous inflammation.
  • To explore Mo90Ce10's mechanism of action and its efficacy as a transdermal delivery platform.

Main Methods:

  • In vitro assessment of Mo90Ce10's ROS scavenging and dsRNA binding capabilities, including its effect on type I interferon responses.
  • In vivo evaluation of Mo90Ce10 in reducing skin inflammation, dsRNA burden, ROS levels, and neutrophil infiltration.
  • Development of a transdermal delivery system by complexing Mo90Ce10 with TD-1 peptide and co-loading methotrexate.

Main Results:

  • Mo90Ce10 demonstrated potent ROS scavenging and direct binding to dsRNA, suppressing inflammatory responses.
  • In vivo studies showed significant reduction in disease severity, inflammation, ROS, and neutrophil infiltration.
  • The developed transdermal platform enhanced drug penetration and therapeutic efficacy while reducing disease recurrence.

Conclusions:

  • Mo90Ce10 acts as a multifunctional agent targeting both dsRNA and ROS, offering a novel approach for inflammatory skin diseases.
  • The Mo90Ce10-based transdermal platform shows promise for improved treatment delivery and efficacy in managing inflammatory conditions.