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Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes

Mahboob Ali, Sameh Girgis, Atif Hassan

    Coronary Artery Disease
    |April 14, 2018
    PubMed

    Insights

    Cardiovascular disease, particularly atherosclerotic coronary artery disease, remains a significant global health challenge. This review explores its scope, pathobiology, biomarkers, and the role of inflammation in precision medicine for improved diagnosis and management.

    Area of Science:

    • Cardiovascular Medicine
    • Pathobiology
    • Precision Medicine

    Background:

    • Cardiovascular disease (CVD) and atherosclerotic coronary artery disease (CAD) represent a major global health and economic burden.
    • Despite historical observations and evolving knowledge of atherosclerosis, significant gaps in understanding persist.
    • Key pathobiological aspects include inflammation, vascular injury response, and impaired homeostasis.

    Purpose of the Study:

    • To summarize the current scope and challenges of coronary artery disease.
    • To review emerging pathobiological constructs, clinical phenotypes, and biomarkers.
    • To discuss the 'inflammation hypothesis' and the integration of pathobiology with precision medicine for future advancements.

    Main Methods:

    • Literature review and synthesis of existing research on atherosclerosis and coronary artery disease.
    • Analysis of current understanding of disease pathobiology, including inflammation and vascular injury.
    • Examination of clinical trials, biomarkers, and the application of precision medicine.

    Main Results:

    • Coronary artery disease presents a substantial and ongoing global health concern.
    • Emerging research highlights inflammation's role in atherosclerosis, alongside vascular injury and homeostasis.
    • Potential biomarkers and clinical trial data are being evaluated to test the 'inflammation hypothesis'.

    Conclusions:

    • A comprehensive understanding of coronary artery disease pathobiology is crucial for advancing diagnosis and management.
    • Precision medicine, informed by pathobiology, offers a foundation for personalized strategies in prevention and treatment.
    • Further research integrating pathobiology and clinical data is essential for optimizing patient outcomes.

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