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Updated: Feb 11, 2026

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
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Customizing poly(lactic-co-glycolic acid) particles for biomedical applications.

Edyta Swider1, Olga Koshkina1, Jurjen Tel2

  • 1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands.

Acta Biomaterialia
|April 14, 2018
PubMed
Summary

Poly(lactic-co-glycolic acid) (PLGA) particles are versatile biodegradable polymers for nanomedicine. This review details PLGA particle preparation and modification, guiding researchers to optimize properties for specific biomedical applications.

Keywords:
Drug deliveryImagingParticlesPoly(lactic-co-glycolic acid)Theranostics

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Polymer Chemistry

Background:

  • Polymeric nanoparticles, particularly poly(lactic-co-glycolic acid) (PLGA), are crucial in nanomedicine due to their biocompatibility and biodegradability.
  • PLGA particles offer versatility for applications including drug delivery and advanced imaging.
  • Understanding particle synthesis is key to harnessing their full potential in biological systems.

Purpose of the Study:

  • To provide a comprehensive overview of poly(lactic-co-glycolic acid) (PLGA) particle formulation techniques and modifications.
  • To guide researchers in selecting or designing optimal PLGA particles for specific biomedical applications.
  • To highlight recent advancements in PLGA particle synthesis and their impact on biological applications.

Main Methods:

  • Discussion of established and novel preparation techniques, including microfluidics and Particle Replication in Non-wetting Templates (PRINT).
  • Exploration of particle modifications to achieve tailored or responsive properties, such as Janus and upconversion particles.
  • Emphasis on adapting synthesis methods to meet the demands of specific biomedical applications.

Main Results:

  • Detailed examination of various PLGA particle synthesis methods and their influence on particle characteristics.
  • Highlighting innovative approaches like microfluidics and PRINT for precise particle fabrication.
  • Demonstration of how PLGA chemistry can be modified to address significant biological challenges.

Conclusions:

  • The choice of preparation method significantly impacts PLGA particle properties and their biological implications.
  • Tailoring PLGA particle synthesis is essential for successful translation into biomedical applications.
  • Adaptable PLGA particle design holds promise for solving critical needs in medicine and biology.