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Relationship between blood parameters and Clonorchis sinensis infection: A retrospective single center study

Huaping Chen1, Siyuan Chen1, Zhili Huang1

  • 1Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.

International Immunopharmacology
|April 14, 2018
PubMed

Insights

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and eosinophil-to-lymphocyte ratio (ELR) can help detect Clonorchis sinensis infections. ELR demonstrated the highest diagnostic accuracy, and a model using age and NLR effectively differentiated disease stages.

Area of Science:

  • Medical research
  • Parasitology
  • Clinical diagnostics

Background:

  • Clonorchis sinensis infection can lead to biliary obstruction and cholangiocarcinoma.
  • Accurate diagnostic markers for C. sinensis infection and its complications are crucial.
  • Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and eosinophil-to-lymphocyte ratio (ELR) are potential inflammatory markers.

Purpose of the Study:

  • To investigate the diagnostic value of NLR, PLR, and ELR in patients with C. sinensis infection.
  • To assess the relationship between these ratios and biliary obstruction stages.
  • To evaluate their utility in differentiating C. sinensis-related cholelithiasis and cholangiocarcinoma.

Main Methods:

  • Retrospective analysis of 151 patients with C. sinensis infections and 53 healthy controls.
  • Calculation and comparison of NLR, PLR, and ELR between groups.
  • Logistic regression modeling using age and NLR for disease differentiation.
  • Receiver operating characteristic (ROC) analysis to determine diagnostic accuracy and compare with cancer antigen 19-9 (CA19-9).

Main Results:

  • NLR, PLR, and ELR were significantly higher in C. sinensis-infected patients compared to healthy individuals.
  • ELR exhibited the highest diagnostic accuracy for C. sinensis infection (sensitivity 62.9%, specificity 92.5%).
  • A logistic regression model (age and NLR) showed high sensitivity (88.89%) and specificity (83.78%) for differentiating C. sinensis-related cholelithiasis from untreated C. sinensis.
  • PLR showed acceptable efficiency in distinguishing C. sinensis-related cholelithiasis from cholangiocarcinoma, though CA19-9 performed better.

Conclusions:

  • NLR, PLR, and ELR are valuable supplementary markers for detecting C. sinensis infections and associated diseases.
  • ELR shows promise as a diagnostic marker for C. sinensis infection.
  • Inflammatory markers like NLR and PLR may aid in differentiating C. sinensis-related biliary conditions.

Keywords:
Clonorchis sinensisDiagnosisEosinophil-to-lymphocyte ratioLogistic regressionNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratio

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