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Comparative Evaluation of the Mindray BS2000 and Roche Cobas 8000 Platforms using Serum HDL-C, LDL-C, Apo A1, Apo B,
Ran Li1, Xuelian Ruan1, Mingxing Chen1
1Department of Laboratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning, Guangxi, China.
Objective:
Biochemical items play a significant role in clinical decision-making, so this study aims to evaluate the performance of different biochemical platforms.
Methods:
We collected 1,524 serum samples that were centrifuged, and plasma was analyzed for HDL-C, LDL-C, Apo A1, Apo B, PA, and Fs-CRP with the Mindray BS2000M and Roche Cobas 8000 platforms. The results were evaluated by a non-parametric two-related sample test, Passing-Bablok regression analysis, Weighted Least Square analysis (WLS), and Bland-Altman analysis according to CLSI EP09-A3, EP5-A2, and EP15-A3.
Results:
Between the two systems, there were statistically significant differences in the average bias of LDL-C, Apo A1, Apo B, PA, and Fs-CRP (P<0.001). Moreover, the acceptable clinical performance evaluation test results showed that the differences between low medical decision levels of HDL-C, LDL-C, Apo A1, Apo B, and Fs-CRP in the two systems were clinically unacceptable, while the other items were acceptable.
Conclusion:
These findings suggest that the two platforms have good correlation and consistency in high-concentration medical decision levels in HDL-C, LDL-C, Apo A1, Apo B, and Fs-CRP, and all levels of PA in the two platforms are interchangeable and can replace each other.
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