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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p53: emerging roles in stem cells, development and beyond.

Abhinav K Jain1, Michelle Craig Barton1

  • 1Department of Epigenetics and Molecular Carcinogenesis, Center for Stem Cell and Development Biology, Center for Cancer Epigenetics, The University of Texas MD Anderson UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA ajain@mdanderson.org mbarton@mdanderson.org.

Development (Cambridge, England)
|April 15, 2018
PubMed
Summary
This summary is machine-generated.

The tumor suppressor p53 protein is crucial in cancer, but its roles in mammalian development and cell differentiation are now being uncovered. Recent research highlights these complementary functions, expanding our understanding beyond cancer suppression.

Keywords:
DevelopmentDifferentiationEmbryonic stem cellslncRNAp53

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cancer Research

Background:

  • Mutations in the p53 gene are prevalent in human cancers.
  • p53 is extensively studied for its tumor suppressor functions.
  • p53's roles in mammalian development and cell differentiation have been historically under-explored.

Purpose of the Study:

  • To review recent advances in understanding p53 functions in mammalian development.
  • To highlight the significance and mechanisms of p53 in cell differentiation.
  • To present a comprehensive view of p53's roles, complementing its known tumor suppressor functions.

Main Methods:

  • Genomic profiling of embryonic stem cells.
  • Literature review of recent findings on p53.
  • Analysis of p53's involvement in cell differentiation and development.

Main Results:

  • Genomic studies reveal novel p53 functions in embryonic stem cells.
  • p53 plays significant roles in mammalian cell differentiation.
  • These developmental roles complement p53's established tumor suppressor activities.

Conclusions:

  • Recent findings underscore the importance of p53 in development.
  • p53's functions extend beyond tumor suppression to critical developmental processes.
  • A broader understanding of p53 is emerging, integrating its roles in both cancer and development.