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Updated: Feb 11, 2026
09:31
Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas
Published on: May 2, 2022
2.4K
Scarless wound healing: From development to senescence.
Harris Pratsinis1, Eleni Mavrogonatou1, Dimitris Kletsas1
1Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", Athens, Greece.
Advanced Drug Delivery Reviews
|April 15, 2018
Summary
Skin wound healing differs significantly from fetal regeneration, often resulting in scarring in adults. This review explores wound repair from embryonic development through aging, considering factors like senescence and scarless healing.
Area of Science:
- Regenerative Medicine
- Developmental Biology
- Aging Research
Background:
- Cutaneous wound healing in adults prioritizes rapid barrier restoration, typically leading to scar formation, a fibrotic and dysfunctional tissue.
- Conversely, fetal wound healing demonstrates scarless regeneration, highlighting distinct biological mechanisms.
- The capacity for tissue repair declines with age, though certain conditions in the elderly may promote higher quality repair.
Purpose of the Study:
- To present a comprehensive review of skin wound healing and scarring processes.
- To examine the spectrum of wound repair from embryonic development to aging.
- To discuss the role of cellular senescence in wound healing and tissue regeneration.
Main Methods:
- Literature review synthesizing data on embryonic, adult, and aged wound healing.
- Analysis of mechanisms underlying scar formation versus scarless regeneration.
- Exploration of the impact of cellular senescence on tissue repair quality.
Main Results:
- Adult wound healing results in scar tissue, impairing skin function.
- Fetal wound healing achieves scarless regeneration.
- Senescent cells, while implicated in chronic wounds, may transiently aid tissue repair.
Conclusions:
- Understanding the differences between fetal and adult wound healing is crucial for advancing regenerative medicine.
- Cellular senescence presents a complex role in wound repair, potentially offering therapeutic targets.
- Aging impacts wound healing capacity, necessitating further research into age-related repair mechanisms.
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