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Demonstration of the bactericidal effects of the boron neutron capture reaction
Charles A Maitz1, John D Brockman2, Ming Yang3
1Department of Veterinary Medicine and Surgery, University of Missouri, Columbia 65211, USA; University of Missouri Research Reactor, University of Missouri, Columbia 65211, USA.
Abstract:
This pilot study represents a paradigm shift, using BNCT for the treatment of bacterial overgrowth on surgically implanted medical devices. In this study, titanium diboride disks were inoculated with S. aureus and irradiated in a thermal neutron beam. After a delivery of 2.6 × 1012 n/cm2 the surviving fraction of S. aureus on an irradiated disk was 3.1 × 10-5 when compared with non-irradiated controls. This pilot study demonstrates proof of principle of boron neutron capture therapy for infection control (BNCIC).
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