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Comparative performances of lactoferrin-loaded liposomes under in vitro adult and infant digestion models

Weilin Liu1, Junmeng Lu1, Aiqian Ye2

  • 1School of Food and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

Food Chemistry
|April 16, 2018
PubMed

Insights

Liposomes carrying lactoferrin are more stable in infant digestion models than adult ones. This suggests liposomes could be effective nutrient carriers for infant foods.

Area of Science:

  • Food Science
  • Biotechnology
  • Materials Science

Background:

  • Understanding liposome stability in infant digestion is crucial for developing effective nutrient delivery systems.
  • Essential proteins like lactoferrin require protection during gastrointestinal transit.

Purpose of the Study:

  • To investigate the behavior and stability of lactoferrin-loaded liposomes in infant gastrointestinal models.
  • To compare liposome digestion in infant versus adult in vitro models.

Main Methods:

  • Utilized in vitro digestion models simulating infant and adult gastrointestinal environments.
  • Analyzed lactoferrin hydrolysis, free fatty acid release, and phospholipid membrane alterations using pH and FTIR.
  • Employed particle tracking analysis and Transmission Electron Microscopy (TEM) to assess liposome structural integrity.

Main Results:

  • Lactoferrin-loaded liposomes exhibited reduced hydrolysis of encapsulated lactoferrin under infant model conditions.
  • Significantly lower free fatty acid release (500 ± 43 μM mL⁻¹) was observed in the infant model compared to the adult model (1000 ± 66 μM mL⁻¹).
  • Infant model digestion resulted in less alteration of phospholipid membrane functional groups and preserved liposome structure.

Conclusions:

  • Liposomes demonstrate enhanced stability in simulated infant gastrointestinal conditions.
  • These findings highlight the potential of liposomes as viable carriers for delivering functional proteins and nutrients in infant nutrition.

Keywords:
DigestionInfantLactoferrinLiposomesStructure

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