Related Experiment Video

Updated: Feb 11, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

10.9K

Post stroke depression: The sequelae of cerebral stroke

Jyotirekha Das1, Rajanikant G K1

  • 1School of Biotechnology, National Institute of Technology Calicut, Calicut, 673601, India.

Neuroscience and Biobehavioral Reviews
|April 16, 2018
PubMed

Insights

Post-stroke depression (PSD) affects one-third of stroke survivors, hindering recovery and increasing relapse risks. Research is ongoing to understand its causes, improve screening, and optimize treatments for better patient outcomes.

Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Post-stroke depression (PSD) is a prevalent complication, affecting approximately 33% of stroke survivors.
  • PSD negatively impacts motor and cognitive rehabilitation, prolongs recovery, and increases the risk of recurrent neurovascular events.
  • Both biological and psychological factors contribute to the development of PSD, necessitating comprehensive research into its etiology.

Purpose of the Study:

  • To review current evidence on predictors, incidence, prevalence, and etiology of PSD.
  • To discuss existing screening and diagnostic approaches for PSD.
  • To explore therapeutic modalities, management strategies, and the influence of pre-stroke depression on PSD.

Main Methods:

  • Literature review of existing evidence on post-stroke depression.
  • Analysis of studies focusing on risk factors, predictors, and etiology.
  • Examination of current screening, diagnostic, and therapeutic approaches.

Main Results:

  • Biological and psychological factors play significant roles in PSD.
  • Current screening and diagnostic tools for PSD require further development.
  • Pharmacotherapy and psychotherapy are key treatment modalities, with ongoing research into pathophysiology.

Conclusions:

  • Further research is essential to elucidate the pathophysiology of PSD.
  • Development of a suitable screening tool is needed for early detection and intervention.
  • Optimizing management strategies, including pharmacotherapy and psychotherapy, is crucial for improving patient outcomes.

Keywords:
EtiologyIschemic strokePost stroke depressionPre-stroke depressionPredictorsScreeningTherapeutics

More Related Videos

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.6K
Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery07:26

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

8.4K

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.2K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.9K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.5K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.5K