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[Natural cycle for frozen-thawed embryo transfer: Spontaneous ovulation or triggering by HCG]
S Huberlant1, M Vaast2, T Anahory3
1Département de gynécologie obstétrique et médecine de la reproduction, hopital universitaire Caremeau, place du Professeur R. Debré, 30029 Nîmes, France.
Gynecologie, Obstetrique, Fertilite & Senologie
|April 16, 2018
Summary
Recombinant human chorionic gonadotrophin (r-hCG) triggering for ovulation induction in natural frozen-thawed embryo transfer (FET) cycles shows comparable pregnancy outcomes to spontaneous ovulation. This method also reduces monitoring frequency, simplifying the FET process.
Area of Science:
- Reproductive endocrinology and infertility
- Assisted reproductive technologies (ART)
Background:
- Natural frozen-thawed embryo transfer (FET) cycles are a common approach for infertile patients.
- Ovulation induction timing in natural FET cycles, whether spontaneous or triggered, remains a subject of debate.
- Recombinant human chorionic gonadotrophin (r-hCG) is an option for ovulation triggering.
Purpose of the Study:
- To compare the outcomes of frozen-thawed embryo transfer (FET) in natural cycles.
- To evaluate outcomes based on two ovulation induction methods: spontaneous luteinizing hormone (LH) surge versus r-hCG triggering.
Main Methods:
- Retrospective study of patients undergoing natural cycle FET over one year.
- Group A: Spontaneous LH surge (n=38); Group B: r-hCG triggering (n=43).
- All embryos were vitrified; no luteal phase support was administered.
Main Results:
- No significant differences in implantation rates (31% vs 45%), clinical pregnancy rates (32% vs 51%), or live birth rates (21% vs 32%) between Group A and Group B.
- Group B (r-hCG) required significantly fewer monitoring visits (1.9±0.8 vs 2.5±1, P=0.006).
- Comparable reproductive outcomes with reduced monitoring intensity using r-hCG.
Conclusions:
- Triggering ovulation with r-hCG in natural FET cycles, under strict criteria, yields favorable results.
- r-hCG triggering can simplify the FET protocol, potentially reducing constraints and costs.
- Further consensus is needed, but r-hCG appears a viable option for ovulation induction in normo-ovulating patients undergoing natural FET.
Keywords:
Cycle naturelCycle regimenDéclenchement de l’ovulationFrozen-thawed embryo transferHormone chorionique gonadotropeHuman chorionic gonodotrophinNatural cycleOvulation inductionPréparation endométrialeTransfert d’embryons congelésMore Related Videos
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