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Updated: Feb 11, 2026
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
Necrotizing enterocolitis associated with Clostridium butyricum in a Japanese man
Yukio Sato1,2, Dai Kujirai1,2, Katsura Emoto3,4
1Department of Emergency Medicine Saiseikai Utsunomiya Hospital Tochigi Japan.
Case:
Necrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84-year-old Japanese man developed C. butyricum-related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia.
Outcome:
The patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis. Pathologic findings showed mucosal necrosis and extensive vacuolation with gram-positive rods in the necrotic small intestine. Blood culture tests revealed C. butyricum infection. The patient's condition improved after the surgery. He was moved to a rehabilitation hospital on day 66.
Conclusion:
This study suggests that hospitalized adult patients who receive antibiotic treatment are at risk for NEC.
