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Updated: Feb 11, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Published on: July 6, 2019
In situ follow-up of hybrid alginate-silicate microbeads formation by linear rheology
F B Haffner1, N Canilho, B Medronho
1L2CM UMR CNRS-Université de Lorraine, Bvd. des Aiguillettes, BP 70239, Vandoeuvre-lès-Nancy F-54506, France. andreea.pasc@univ-lorraine.fr.
Abstract:
Hybrid alginate-silicate microbeads of about 10-20 μm were synthesized by combining alginate crosslinking, silica condensation in a one pot approach using a food grade emulsion as template. A fine tuning of the formulation composition (alginate, silica and calcium sources) is necessary in order to obtain core-shell microbeads instead of unshaped and irregular fragments or even perforated spherical beads. Importantly, in situ linear rheology provides insights into the reaction mechanism as a result of the rheological fingerprint profile obtained during beads formation.
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