Related Experiment Video

Updated: Feb 11, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.7K

Hypertension and Aortic Stenosis: A Review

Allen Rassa1, Firas Zahr1

  • 1Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.

Current Hypertension Reviews
|April 17, 2018
PubMed

Insights

Treating hypertension in patients with aortic stenosis is complex. Angiotensin-converting enzyme (ACE) inhibitors are the most studied agents for managing high blood pressure in these patients.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Aortic stenosis and hypertension frequently coexist, presenting distinct left ventricular systolic overload.
  • Combined conditions can lead to adverse left ventricular remodeling, increased mortality, and heart failure.
  • Managing hypertension in aortic stenosis patients poses clinical challenges due to limited evidence.

Purpose of the Study:

  • To review the pathophysiology of combined aortic stenosis and hypertension.
  • To examine the impact on left ventricular remodeling.
  • To provide recommendations for antihypertensive therapy in this patient population.

Main Methods:

  • A comprehensive online literature review was conducted.
  • Relevant published literature on hypertension and aortic stenosis was identified and analyzed.

Main Results:

  • The manuscript reviews the pathophysiology and effects of combined aortic stenosis and hypertension on the left ventricle.
  • General recommendations for medical therapy are provided.
  • Data on specific antihypertensive agents were reviewed.

Conclusions:

  • Coexisting aortic stenosis and hypertension complicate diagnosis and symptom assessment.
  • Treating hypertension in severe aortic stenosis is challenging.
  • Angiotensin-converting enzyme (ACE) inhibitors are the most studied antihypertensive agents in this context.
Abstract

Keywords:
Aortic stenosisclinical practiceheart failurehypertensionmortalityvalvuloarterial impedance.

More Related Videos

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.7K
A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury07:10

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Published on: March 31, 2023

1.6K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
744
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
957
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
490