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Hypertension and Aortic Stenosis: A Review
1Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.
Current Hypertension Reviews
|April 17, 2018
Summary
Treating hypertension in patients with aortic stenosis is complex. Angiotensin-converting enzyme (ACE) inhibitors are the most studied agents for managing high blood pressure in these patients.
Area of Science:
- Cardiology
- Internal Medicine
- Pharmacology
Background:
- Aortic stenosis and hypertension frequently coexist, presenting distinct left ventricular systolic overload.
- Combined conditions can lead to adverse left ventricular remodeling, increased mortality, and heart failure.
- Managing hypertension in aortic stenosis patients poses clinical challenges due to limited evidence.
Purpose of the Study:
- To review the pathophysiology of combined aortic stenosis and hypertension.
- To examine the impact on left ventricular remodeling.
- To provide recommendations for antihypertensive therapy in this patient population.
Main Methods:
- A comprehensive online literature review was conducted.
- Relevant published literature on hypertension and aortic stenosis was identified and analyzed.
Main Results:
- The manuscript reviews the pathophysiology and effects of combined aortic stenosis and hypertension on the left ventricle.
- General recommendations for medical therapy are provided.
- Data on specific antihypertensive agents were reviewed.
Conclusions:
- Coexisting aortic stenosis and hypertension complicate diagnosis and symptom assessment.
- Treating hypertension in severe aortic stenosis is challenging.
- Angiotensin-converting enzyme (ACE) inhibitors are the most studied antihypertensive agents in this context.
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