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Cu-Catalyzed Aerobic Oxidative Sulfuration/Annulation Approach to Thiazoles via Multiple Csp3-H Bond Cleavage
Xiaoyang Wang1, Xu Qiu1, Jialiang Wei1
1State Key Laboratory of Natural and Biomimetic Drugs, and Medical and Health Analysis Center , Peking University , Xue Yuan Road 38 , Beijing 100191 , China.
Abstract:
A novel and practical Cu-catalyzed aerobic oxidative synthesis of thiazoles was developed. This chemistry for the first time achieved thiazole construction from simple aldehydes, amines, and element sulfur through multiple Csp3-H bond cleavage processes. Molecular oxygen was used as a green oxidant in this oxidative protocol. The substrate scope is broad with the tolerance of aliphatic amines. The mechanistic study might promote the reaction design for a new sulfuration/annulation reaction with readily available element sulfur.
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