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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Transitioning Patients With Iron Overload From Exjade to Jadenu
Sara M Tinsley1, Christine M Hoehner-Cooper
1H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida (Dr Tinsley); and University of California, San Francisco (UCSF) Benioff Children's Hospital, Oakland, California (Ms Hoehner-Cooper). Sara M. Tinsley, PhD, ARNP, AOCN®, is a malignant hematology nurse practitioner at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. Dr Tinsley is also a member of the Oncology Nursing Society's Oncology Nurse Expert Panel and the Myelodysplastic Syndrome Foundation's International Nurse Leadership Board. Christine M. Hoehner-Cooper, MSN, RN, NP-C, is a nurse practitioner in the Adult Sickle Cell Center at UCSF Benioff Children's Hospital in Oakland, California. She has participated in a number of national sickle cell disease meetings and presented abstracts related to the disease.
Abstract:
Iron overload is a concern for patients who require chronic transfusions as a result of inherited or acquired anemias, including sickle cell disease, thalassemia, and myelodysplastic syndromes. Iron chelation therapy (ICT) is the primary treatment for iron overload in these patients. The ICT deferasirox, which has been available as an oral dispersible tablet for liquid suspension, is now also available as a once-daily, film-coated tablet (FCT). Deferasirox FCT allows greater convenience and may be associated with fewer gastrointestinal side effects versus the original formulation. Dose adjustment increments, determined by titration monitoring, are lower for the FCT because of greater bioavailability.
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