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Updated: Feb 11, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

707

Computation of hemodynamics in eccentric coronary stenosis: A morphological parametric study

Xinzhou Xie, Yabing Li, Songyun Xie

    Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
    |April 18, 2018
    PubMed

    Insights

    Detailed geometry of eccentric coronary stenosis significantly impacts post-stenotic flow. Eccentricity index, stenosis length, and shape are key factors influencing flow recirculation and shear rates, crucial for understanding adverse outcomes.

    Area of Science:

    • Cardiovascular fluid dynamics
    • Biomechanical analysis of coronary stenosis

    Background:

    • Eccentric coronary stenosis causes flow recirculation, potentially leading to adverse outcomes.
    • Complex stenosis geometry is critical for determining post-stenotic flow characteristics.

    Purpose of the Study:

    • To correlate detailed morphological parameters of eccentric coronary stenosis with post-stenotic flow characteristics.
    • Investigate the influence of specific geometric factors on blood flow patterns.

    Main Methods:

    • Computational fluid dynamics (CFD) analysis of idealized eccentric coronary stenosis models.
    • Systematic variation of morphological parameters: eccentricity index (EI), diameter stenosis (DS), stenosis length (SL), and lesion shape.

    Main Results:

    • Recirculation zone length varies with EI (increases for EI < 0.33, decreases for EI > 0.33).
    • Smaller EIs correlate with larger retrograde flow.
    • Increased DS, SL, and sharper stenosis shapes lead to longer recirculation zones and higher maximum shear rates.

    Conclusions:

    • Morphological parameters like EI, SL, and stenosis shape significantly influence post-stenotic flow behavior.
    • Diameter stenosis (DS) is also a critical factor affecting flow dynamics.
    Abstract

    Keywords:
    Eccentric coronary stenosiscomputational fluid dynamics analysismorphological parameterspost-stenotic flow characteristics

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