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17-hydroxiprogesterone values in healthy preterm infants

Víctor Clemente Mendoza-Rojas1, Luis Alfonso Díaz-Martínez1, Gerardo Mantilla-Mora1

  • 1Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia.

Colombia Medica (Cali, Colombia)
|April 18, 2018
PubMed

Insights

17-hydroxyprogesterone (17-OHP) levels are elevated in preterm infants compared to full-term newborns, persisting even at corrected gestational age. This suggests postnatal adaptation may influence these levels, warranting further investigation.

Area of Science:

  • Neonatal Medicine
  • Endocrinology
  • Pediatrics

Background:

  • 17-hydroxyprogesterone (17-OHP) interpretation can be challenging in preterm neonates.
  • Elevated 17-OHP levels in preterm infants may impact diagnostic accuracy.

Purpose of the Study:

  • To evaluate 17-hydroxyprogesterone (17-OHP) values in healthy preterm newborns.
  • To establish reference ranges for 17-OHP until corrected gestational age is reached.

Main Methods:

  • A longitudinal study involving 36 preterm infants.
  • 17-OHP levels measured via ELISA from heel blood.
  • Serial measurements from early postnatal life up to corrected gestational age, compared to 82 full-term infants.

Main Results:

  • Preterm infants (<34 weeks gestational age) exhibit significantly higher 17-OHP values than full-term neonates in the first week.
  • 17-OHP levels decrease but remain elevated compared to full-term infants, even at corrected gestational age (average difference 63.0%).
  • 33.6% of samples from preterm infants exceeded 30 ng/mL.

Conclusions:

  • Elevated 17-OHP in preterm infants may be linked to postnatal adaptive processes.
  • Current 17-OHP reference ranges may not be suitable for preterm populations.
  • A second screening at 37 weeks corrected age is proposed for improved interpretation.
Abstract

Keywords:
17-alpha-HidroxiprogesteroneAdrenal Hyperplasia CongenitalNeonatal screening

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