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17-hydroxiprogesterone values in healthy preterm infants.
Víctor Clemente Mendoza-Rojas1, Luis Alfonso Díaz-Martínez1, Gerardo Mantilla-Mora1
1Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia.
Colombia Medica (Cali, Colombia)
|April 18, 2018
Summary
17-hydroxyprogesterone (17-OHP) levels are elevated in preterm infants compared to full-term newborns, persisting even at corrected gestational age. This suggests postnatal adaptation may influence these levels, warranting further investigation.
Area of Science:
- Neonatal Medicine
- Endocrinology
- Pediatrics
Background:
- 17-hydroxyprogesterone (17-OHP) interpretation can be challenging in preterm neonates.
- Elevated 17-OHP levels in preterm infants may impact diagnostic accuracy.
Purpose of the Study:
- To evaluate 17-hydroxyprogesterone (17-OHP) values in healthy preterm newborns.
- To establish reference ranges for 17-OHP until corrected gestational age is reached.
Main Methods:
- A longitudinal study involving 36 preterm infants.
- 17-OHP levels measured via ELISA from heel blood.
- Serial measurements from early postnatal life up to corrected gestational age, compared to 82 full-term infants.
Main Results:
- Preterm infants (<34 weeks gestational age) exhibit significantly higher 17-OHP values than full-term neonates in the first week.
- 17-OHP levels decrease but remain elevated compared to full-term infants, even at corrected gestational age (average difference 63.0%).
- 33.6% of samples from preterm infants exceeded 30 ng/mL.
Conclusions:
- Elevated 17-OHP in preterm infants may be linked to postnatal adaptive processes.
- Current 17-OHP reference ranges may not be suitable for preterm populations.
- A second screening at 37 weeks corrected age is proposed for improved interpretation.
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