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Epigenetics in assisted reproductive technology.

Yukiko Katagiri1,2, Yukihiro Shibui1,2, Koichi Nagao2

  • 1Department of Obstetrics and Gynecology and.

Reproductive Medicine and Biology
|April 18, 2018
PubMed
Summary

Assisted reproductive technology (ART) may increase risks for epigenetic disorders like Angelman syndrome and Beckwith-Wiedemann syndrome in children. Further research is crucial to ensure the long-term health of offspring conceived via ART.

Keywords:
Beckwith–Wiedemann syndromeassisted reproductive technologyassisted reproductive technology childrenepigeneticslarge offspring syndrome.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Developmental Biology

Background:

  • Assisted reproductive technology (ART) is increasingly used globally.
  • Studies suggest a potential link between ART and epigenetic disorders, including Angelman syndrome (AS) and Beckwith-Wiedemann syndrome (BWS).
  • AS is associated with intellectual disability, while BWS is known as large offspring syndrome (LOS), with both conditions impacting child development.

Purpose of the Study:

  • To investigate the potential association between ART and epigenetic abnormalities in offspring.
  • To determine if ART methods contribute to the increased incidence of syndromes like AS and BWS.
  • To evaluate the implications for the health of future generations conceived through ART.

Main Methods:

  • Review of existing literature on ART and epigenetic disorders.
  • Analysis of potential contributing factors: gamete quality, in vitro culture conditions, and ART procedures.
  • Consideration of findings in cloned animals regarding weight abnormalities.

Main Results:

  • Reported higher rates of AS and BWS in ART-conceived offspring.
  • Observed weight abnormalities in cloned animals, suggesting potential epigenetic influences.
  • Identified inherent gamete characteristics, in vitro culture, and ART methods as possible causative factors.

Conclusions:

  • Conclusive determination of epigenetic abnormalities in ART-conceived children is essential.
  • Understanding these risks is critical for safeguarding the health of subsequent generations.
  • Further research is needed to clarify the relationship between ART and epigenetic health outcomes.