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Group 3 metal trihalide complexes with neutral N-donor ligands - exploring their affinity towards fluoride
Emily Curnock1, William Levason, Mark E Light
1Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK. G.Reid@soton.ac.uk.
Dalton Transactions (Cambridge, England : 2003)
|April 18, 2018
Summary
New scandium fluoride complexes with neutral ligands were synthesized via chloride/fluoride exchange. These complexes show stability in water and potential applications in PET radiopharmaceuticals.
Area of Science:
- Coordination Chemistry
- Organometallic Chemistry
- Materials Science
Background:
- Scandium fluoride complexes with neutral ligands are underexplored.
- Synthesis of novel metal-organic compounds is crucial for materials development.
- Understanding ligand exchange mechanisms informs synthetic strategies.
Purpose of the Study:
- To synthesize and characterize novel scandium fluoride complexes with neutral co-ligands.
- To investigate the fluorination of scandium and other Group 3 metal complexes.
- To explore the structural and chemical properties of these new compounds.
Main Methods:
- Chloride/fluoride exchange reactions using anhydrous [NMe4]F or Me3SnF.
- Characterization by microanalysis, IR, multinuclear NMR (1H, 19F, 45Sc), and X-ray crystallography.
- Stability studies in aqueous solutions and with various anions.
Main Results:
- Successful synthesis of [ScF3(R3-tacn)] (R3 = Me3 or BnMe2) and heterobimetallic Sc-Sn fluoride complexes.
- Stepwise fluorination observed, yielding [ScF2Cl(Me3-tacn)] with a fluoride deficit.
- X-ray structures confirmed the unique coordination environments and Sc-F-Sn bridges in bimetallic species.
Conclusions:
- The first scandium fluoride complexes with neutral ligands, [ScF3(R3-tacn)], were synthesized.
- Heterobimetallic Sc-Sn fluoride complexes exhibit interesting structural dynamics in solution and solid state.
- [ScF3(R3-tacn)] complexes are stable and show potential for 18F PET radiopharmaceutical development.
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