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EZH2 Expression in Naturally Occurring Canine Tumors
Hyun-Ji Choi1, Han-Byul Lee1, Hyun-Kyu Park1
1University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea.
Comparative Medicine
|April 18, 2018
Summary
Enhancer of zeste homolog 2 (EZH2) is overexpressed in many canine tumors, similar to human cancers. This suggests canine tumors are valuable models for developing new EZH2 inhibitor therapies.
Area of Science:
- Oncology
- Molecular Biology
- Veterinary Medicine
Background:
- Enhancer of zeste homolog 2 (EZH2) plays a key role in tumor development and progression.
- The precise mechanisms by which EZH2 drives tumor aggressiveness are not fully understood.
Purpose of the Study:
- To investigate EZH2 expression levels in canine tumors and normal tissues.
- To compare EZH2 expression patterns in canine tissues with corresponding human tissues.
Main Methods:
- Immunohistochemical analysis was employed to detect EZH2 protein levels.
- A range of normal and tumorous canine tissues were examined.
Main Results:
- EZH2 was positively stained in 76 out of 82 canine tumor cases.
- Overexpression of EZH2 was observed in canine lymphoma, melanoma, basal cell tumors, squamous cell carcinoma, and prostate cancer.
- These canine tumors exhibit similar EZH2 overexpression patterns to their human counterparts.
Conclusions:
- Canine tumors share significant similarities with human cancers, particularly in EZH2 expression profiles.
- Spontaneous canine tumors represent promising preclinical models for evaluating EZH2 inhibitors in clinical trials.
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