Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

18.1K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Subatomic Particles03:37

Subatomic Particles

113.9K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
113.9K
Radiation: Applications01:17

Radiation: Applications

1.8K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.8K
Absorption of Radiation01:05

Absorption of Radiation

1.3K
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.3K
Protection of Alcohols02:31

Protection of Alcohols

8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with <sup>131</sup>I.

European journal of nuclear medicine and molecular imaging·2021
Same author

Correction to: Biokinetics, dosimetry and radiation risk in infants after <sup>99m</sup>Tc-MAG3 scans.

EJNMMI research·2021
Same author

Developing and implementing a multi-modality imaging optimization study in paediatric radiology: Experience and recommendations from an IAEA coordinated research project.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2021
Same author

α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [<sup>223</sup>Ra]RaCl<sub>2</sub>-treated prostate cancer patients.

European journal of nuclear medicine and molecular imaging·2021
Same author

Multicentre Trials on Standardised Quantitative Imaging and Dosimetry for Radionuclide Therapies.

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same author

Paediatric nuclear medicine practice: an international survey by the IAEA.

European journal of nuclear medicine and molecular imaging·2019

Related Experiment Video

Updated: Feb 11, 2026

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.6K

Targeted alpha-particle therapy: imaging, dosimetry, and radiation protection.

M Lassmann1, U Eberlein1

  • 1Department of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany.

Annals of the ICRP
|April 18, 2018
PubMed
Summary

Alpha-particle emitters like radium-223 dichloride offer novel cancer therapy by overcoming radiation resistance. Clinical use requires careful imaging, dosimetry, and radiation protection for patients and staff.

Keywords:
Alpha particlesDosimetryImagingOccupational safetyRadiation protectionRadium-223Targeted therapy

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.5K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K

Related Experiment Videos

Last Updated: Feb 11, 2026

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.6K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.5K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiation Therapy

Background:

  • Alpha-particle emitters represent a novel therapeutic class in oncology.
  • Their high linear energy transfer and short range offer potential to overcome radiation resistance.

Purpose of the Study:

  • To illustrate the clinical considerations for alpha-emitter therapy using radium-223 dichloride.
  • To detail imaging, dosimetry, and radiation protection measures.

Main Methods:

  • Intravenous administration of radium-223 dichloride.
  • Gamma camera imaging for tracking distribution.
  • Dosimetry calculations for absorbed alpha dose.

Main Results:

  • Radium-223 dichloride localizes to bone and bone metastases, excreted via the intestines.
  • Absorbed doses of approximately 17 Gy to bone endosteum and 1.7 Gy to red bone marrow were calculated.
  • Outpatient administration is feasible due to low dose rate, with specific handling precautions.

Conclusions:

  • Radium-223 dichloride therapy requires stringent protocols for safe and effective clinical application.
  • Comprehensive patient and staff education on radiation protection is essential.