Multicentre Trials on Standardised Quantitative Imaging and Dosimetry for Radionuclide Therapies

Area of Science:

• Nuclear Medicine
• Medical Imaging
• Radiotherapy

Background:

• Multicenter clinical trials in radionuclide therapy require standardized quantitative imaging for accurate dosimetry.
• Variability in imaging protocols across institutions can compromise data reliability.

Purpose of the Study:

• To review and summarize existing efforts to compare and standardize quantitative imaging techniques using gamma cameras in multicenter radionuclide therapy trials.
• To identify best practices for achieving comparable quantification across different clinical sites.

Main Methods:

• A systematic review of studies comparing or standardizing quantitative imaging in multicenter radionuclide therapy trials.
• Analysis of imaging modalities used, including planar imaging, SPECT/CT, and PET with 124I.
• Assessment of the use of traceable calibration sources and advanced reconstruction techniques.

Main Results:

• Ten studies were identified, with five focusing on standardization for multicenter trials.
• SPECT/CT, often combined with CT, emerged as the preferred method.
• Three studies utilized calibration sources traceable to national standards.

Conclusions:

• Standardization of quantitative imaging is crucial for reliable dosimetry in multicenter radionuclide therapy trials.
• State-of-the-art SPECT/CT systems and reconstruction methods are recommended for consistent and accurate quantification across sites.