Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

535
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
535
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.1K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
Restorative Care01:19

Restorative Care

2.4K
Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
2.4K
Resistors In Series01:10

Resistors In Series

6.7K
A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.7K
Series Resonance01:17

Series Resonance

877
The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
877
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.2K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anal Cancer Screening Prevalence in U.S. Cities and Factors Associated With Screening.

American journal of preventive medicine·2026
Same author

Characterizing Contemporary Management of Major Pediatric Vascular Trauma: A Multiyear, Dual-Center Retrospective Analysis.

Journal of the American College of Surgeons·2026
Same author

Cost-Effectiveness of Home-Based Self-Sampling vs Clinician Sampling for Anal Precancer Screening.

JAMA network open·2026
Same author

Trauma and Aftercare: Adolescent Firearm Injuries at Pediatric Versus Adult Trauma Centers.

The Journal of surgical research·2025
Same author

Differences in Care Practices and Outcomes for Adolescents With Severe TBI: Adult vs Pediatric Trauma Centers.

The American surgeon·2025
Same author

Examining the cost of childcare in general surgery training.

American journal of surgery·2025

Related Experiment Video

Updated: Feb 11, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.6K

Pouch Volvulus in Patients Having Undergone Restorative Proctocolectomy for Ulcerative Colitis: A Case Series.

Rachel M Landisch1, Paul M Knechtges2, Mary F Otterson1,3

  • 1Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Diseases of the Colon and Rectum
|April 18, 2018
PubMed
Summary

Pouch volvulus, a rare complication after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis, presents with abdominal pain and obstipation. Early diagnosis and treatment, often surgical, can preserve pouch function and improve patient outcomes.

More Related Videos

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

884
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Related Experiment Videos

Last Updated: Feb 11, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.6K
Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

884
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology
  • Colorectal Surgery

Background:

  • Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) enhances quality of life for ulcerative colitis patients.
  • Pouch volvulus is a rare but serious complication following IPAA, often presenting as bowel obstruction.
  • Delayed diagnosis of pouch volvulus can lead to increased morbidity.

Purpose of the Study:

  • To identify symptoms associated with IPAA volvulus.
  • To outline successful management strategies for pouch salvage in IPAA volvulus cases.
  • To improve early diagnosis and treatment of this rare complication.

Main Methods:

  • A case series design was employed.
  • Data were collected from a tertiary referral center for ulcerative colitis.
  • Six patients diagnosed with IPAA volvulus between 2010 and 2015 were analyzed.

Main Results:

  • Four of six patients with pouch volvulus had undergone laparoscopic pouch creation and presented symptoms early post-surgery.
  • Common symptoms included abdominal pain and obstipation; preceding complications were pouch ulceration and pouchitis.
  • CT scans were most effective for diagnosis, with management primarily involving surgery (excision, pexy, detorsion) or endoscopic detorsion, both yielding low morbidity.

Conclusions:

  • IPAA volvulus is a rare, challenging cause of bowel obstruction in ulcerative colitis patients.
  • Recognizing symptoms like pouch ulceration and acute obstipation is crucial for prompt workup.
  • Early, multimodal diagnosis is essential to prevent necrosis and preserve pouch function.