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Humoral regulation of malignant erythropoiesis
A 4-year-old girl with acute DiGuglielmo's syndrome exhibited an unusually malignant erythropoietic proliferation as evidenced by an extremely high number of actively dividing nucleated erythroid cells in the peripheral blood and the bone marrow. The ransfusion of erythrocytes to the patient resulted in a marked decrease in the size of the liver, spleen, and the number of nucleated erythroid cells. These clinical and hematological events were associated with a reduction in the activity of plasma erythropoietin. The above findings suggested that the neoplastic nature of the erythroid elements and their lack of autonomy are not mutually exclusive.
A 4-year-old girl with acute DiGuglielmo's syndrome exhibited an unusually malignant erythropoietic proliferation as evidenced by an extremely high number of actively dividing nucleated erythroid cells in the peripheral blood and the bone marrow. The ransfusion of erythrocytes to the patient resulted in a marked decrease in the size of the liver, spleen, and the number of nucleated erythroid cells. These clinical and hematological events were associated with a reduction in the activity of plasma erythropoietin. The above findings suggested that the neoplastic nature of the erythroid elements and their lack of autonomy are not mutually exclusive.