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13:05
De Novo Generation of Somatic Stem Cells by YAP/TAZ
Published on: May 7, 2018
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Crosstalk between YAP/TAZ and Notch Signaling.
Antonio Totaro1, Martina Castellan1, Daniele Di Biagio1
1Department of Molecular Medicine (DMM), University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy.
Trends in Cell Biology
|April 19, 2018
Summary
Cell behavior coordination in tissues is complex. Crosstalk between YAP/TAZ transcription factors and Notch signaling impacts cell renewal, differentiation, and tissue development.
Area of Science:
- Cellular Biology
- Developmental Biology
- Regenerative Medicine
Background:
- Understanding how cell behavior is orchestrated by tissue needs, size, and developmental stage is crucial.
- This knowledge is essential for advancing morphogenesis, self-organization, regenerative medicine, and treating diseases like cancer and genetic disorders.
Purpose of the Study:
- To outline a novel mechanism involving the interplay between YAP/TAZ transcription factors and Notch signaling.
- To elucidate how this crosstalk influences fundamental cellular processes and tissue-level organization.
Main Methods:
- This review synthesizes current research on YAP/TAZ and Notch signaling pathways.
- It integrates findings related to cell behavior, stem cell dynamics, and tissue development.
Main Results:
- The crosstalk between YAP/TAZ and Notch signaling significantly influences cell self-renewal and stem cell differentiation.
- This interaction also plays a key role in cell fate decisions, epithelial-stromal interactions, and inflammation.
- Furthermore, it impacts morphogenesis and large-scale gene oscillations.
Conclusions:
- The interplay between YAP/TAZ and Notch signaling provides a unifying framework for understanding tissue orchestration.
- This mechanism has broad implications for developmental biology, regenerative medicine, and disease pathology.
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