[The chalone-antichalone system, and mechanisms regulating granulocytopoiesis]

The normal physiological balance between granylocytic chalone and antichalone is shown to be significantly upset where an inflammatory focus is present, with segmented neutrophils activated by cell breakdown products producing, for the most part, a stimulator of cell proliferation. It is also shown that the production of tissue-specific regulators in inflammation depends on the functional state of the entire mature neutrophil pool. The mechanisms of intrasystemic granulocytopoiesis regulation have been unraveled.