Related Experiment Video

Updated: Feb 11, 2026

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.7K

Ranolazine: A true pluripotent cardiovascular drug or jack of all trades, master of none?

Alice Mezincescu1, V J Karthikeyan2, Sunil K Nadar3

  • 1Cardiovascular & Diabetes Research Unit, University of Aberdeen, Aberdeen, UK.

Sultan Qaboos University Medical Journal
|April 19, 2018
PubMed

Insights

Ranolazine offers a unique cardiovascular treatment option. Unlike other medications, it improves symptoms without significantly affecting blood pressure or heart rate, making it valuable for various heart conditions.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Cardiovascular disease (CVD) is a major global health concern.
  • Many CVD patients require medical therapy for prognosis and symptom management.
  • Existing treatments like beta-blockers and calcium channel blockers can lower blood pressure in patients with already low resting pressures.

Purpose of the Study:

  • To review current evidence on ranolazine's use in cardiovascular conditions.
  • To evaluate if ranolazine is a versatile cardiovascular agent or a specialized drug.

Main Methods:

  • Literature review of studies on ranolazine in cardiovascular diseases.
  • Analysis of ranolazine's effects on blood pressure and heart rate.
  • Examination of ranolazine's efficacy in ischaemic heart disease, heart failure, and arrhythmias.

Main Results:

  • Ranolazine demonstrates efficacy in various cardiovascular conditions.
  • It does not significantly impact blood pressure or heart rate.
  • Evidence supports its use for symptom relief and potentially prognosis.

Conclusions:

  • Ranolazine presents a promising therapeutic profile for cardiovascular conditions.
  • Its unique mechanism offers an alternative to traditional agents with hemodynamic side effects.
  • Further research may solidify its role as a pluripotent cardiovascular agent.

Keywords:
Cardiovascular AgentsCardiovascular DiseasesDrug TherapyIschemic Heart DiseaseRanolazine

More Related Videos

Detection of True IgE-expressing Mouse B Lineage Cells09:40

Detection of True IgE-expressing Mouse B Lineage Cells

Published on: December 1, 2014

11.5K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.1K

Related Concept Videos

Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
1.6K
True Stress and True Strain01:28

True Stress and True Strain

Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
864
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Master Transcription Regulators02:23

Master Transcription Regulators

2.8K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.3K
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.2K