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Elevated Serum IgG4 Levels in a Young Patient with Polyserositis and Necator americanus Infection
Giuseppe D Sanna1, Roberto Manetti2, Valentina de Filippo1
1U.O.C. Cardiologia, Ospedale "SS Annunziata" AOU Sassari, Via Enrico De Nicola, 07100 Sassari, Italy.
Abstract:
IgG4-related disease is a fibroinflammatory systemic condition characterized by tumefactive lesions, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 concentrations. It has been described in virtually every organ system. Autoimmunity and infectious agents are potential immunologic triggers in IgG4-related disease. Herein, we describe a peculiar case of effusive-constrictive pericarditis in an 18-year-old boy with polyserositis and concomitant Necator americanus infection.
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