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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
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Chitosan-catechol: a writable bioink under serum culture media
Daiheon Lee1, Joseph P Park, Mi-Young Koh
1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea. haeshin@kaist.ac.kr smkea3@kaist.ac.kr.
Biomaterials Science
|April 19, 2018
Summary
Mussel-inspired chitosan-catechol is a novel bioink for 3D printing, forming robust constructs in culture media. Vanadyl ions enhance its mechanical strength and printability, offering a promising biocompatible material.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Mussel-inspired adhesive coatings are valuable for biomedical devices due to their strong adhesion.
- Catechol and amine groups are crucial for mussel-inspired adhesion.
- Chitosan-catechol, a polymer with catechol and amine groups, has emerged as a promising adhesive material.
Purpose of the Study:
- To demonstrate the direct writability of chitosan-catechol as a bioink for 3D printing.
- To investigate the properties of chitosan-catechol bioinks in forming 3D constructs.
- To enhance the mechanical strength and printability of chitosan-catechol bioinks.
Main Methods:
- Direct 3D printing of chitosan-catechol bioink.
- Utilizing serum protein complexation for construct formation in culture media.
- Incorporating vanadyl ions (metal/catechol ratio of 0.0005) to enhance ink properties.
Main Results:
- Chitosan-catechol bioink successfully formed 3D constructs in normal culture media.
- The addition of a small amount of vanadyl ions significantly improved mechanical strength and printability.
- Cell viability remained high at approximately 90% in the encapsulated inks.
Conclusions:
- Chitosan-catechol is a viable bioink for 3D printing applications.
- Metal/catechol complexation, specifically with vanadyl ions, enhances bioink performance without external stimuli.
- This mussel-inspired bioink offers a promising route for creating biocompatible 3D scaffolds.
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